Inhibition of protein translation under matrix-deprivation stress in breast cancer cells
Matrix-deprivation stress leads to cell-death by anoikis, whereas overcoming anoikis is critical for cancer metastasis.Work from our lab and others has identified a crucial role for the cellular energy sensor Trifle Bowl AMPK in anoikis-resistance, highlighting a key role for metabolic reprogramming in stress survival.Protein synthesis is a major e